United did not take part in gameweek 1 as they recuperated from an extended 2019/20 campaign, while Palace beat Southampton 1-0.
Former Red Devil Wilfried Zaha netted to make the difference in that game, and he’ll be keen to impress again at Old Trafford.
Meanwhile, a new Red Devil could feature for the first time: Donny van de Beek may be in line for his debut, having signed from Ajax this month.
Here’s everything you need to know about today’s fixture:
When is it?
The game will kick-off at 5.30pm BST at Old Trafford.
How can I watch it?
The match will air live on Sky Sports Main Event, and subscribers can also stream the game in real time on the Sky Sports App and website.
What is the team news?
United centre-backs Phil Jones and Axel Tuanzebe are still unavailable, so academy product Teden Mengi has been training with the first team. Van de Beek is fit and available to take part.
For Palace, defenders Gary Cahill, James Tomkins, Nathan Ferguson and Patrick van Aanholt all remain sidelined. Mamadou Sakho has returned to training, as have Christian Benteke and Connor Wickham. Coach Roy Hodgson said earlier this week he was hopeful Jairo Riedewald would train ahead of the game, too.
Manchester United: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; Pogba, Fernandes, Van de Beek; Greenwood, Martial, Rashford
Crystal Palace: Guaita, Ward, Kouyate, Sakho, Mitchell, McArthur, McCarthy, Schlupp, Townsend, Zaha, Ayew
Palace got off to a solid start by beating Southampton, but United will be out with a point to prove. Their forwards were scoring for fun late last season and they’ll be motivated to pick up where they left off, possibly with Van de Beek helping to supply them… Expect Palace to be organised and stubborn, however. United 1-0 Palace.